GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs910316 | 1 | rs10149880 | chr14:75633008 | EIF2B2 | chr14:75469612-75476292:+ | -0.2 | -5.56 | 3.45E-8 | Height |
| BRCA | cis | rs910316 | 1 | rs10149880 | chr14:75633008 | MLH3 | chr14:75480467-75518235:- | -0.22 | -6.95 | 6.54E-12 | Height |
| BRCA | cis | rs7578199 | 1 | rs10153800 | chr2:242179134 | FARP2 | chr2:242295711-242434255:+ | 0.14 | 3.59 | 0.000342 | Chronic lymphocytic leukemia |
| BRCA | cis | rs7647973 | 1 | rs10155014 | chr3:49432321 | AMT | chr3:49454212-49460012:- | 0.14 | 4.97 | 7.82E-7 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs10155014 | chr3:49432321 | CCDC36 | chr3:49235861-49295537:+ | 0.1 | 3.86 | 0.000122 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs10155014 | chr3:49432321 | NCKIPSD | chr3:48711280-48723334:- | 0.17 | 4.28 | 2.02E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs10155014 | chr3:49432321 | P4HTM | chr3:49027341-49044579:+ | 0.1 | 4.12 | 4.11E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs10155014 | chr3:49432321 | WDR6 | chr3:49044637-49053386:+ | -0.14 | -4.34 | 1.56E-5 | Menarche (age at onset) |
| BRCA | cis | rs4660306 | 1 | rs10157597 | chr1:45990278 | CCDC163P | chr1:45960581-45965646:- | -0.82 | -27.84 | 1.19E-128 | Homocysteine levels |
| BRCA | cis | rs4660306 | 1 | rs10157597 | chr1:45990278 | MMACHC | chr1:45965856-45976737:+ | -0.15 | -4.33 | 1.66E-5 | Homocysteine levels |
| BRCA | cis | rs10160456 | 1 | rs10160456 | chr11:27336704 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.22 | 2.66E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10160687 | chr11:27337183 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.22 | 2.66E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs11174436 | 1 | rs10160868 | chr12:62795433 | FAM19A2 | chr12:62102043-62653925:- | 0.17 | 3.75 | 0.000185 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs11174436 | 1 | rs10160955 | chr12:62793195 | FAM19A2 | chr12:62102043-62653925:- | 0.17 | 3.66 | 0.000266 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs7178375 | 1 | rs10163148 | chr15:31212684 | MTMR15 | chr15:31196055-31235307:+ | 0.14 | 3.53 | 0.000438 | Hypertriglyceridemia |